Non-globular proteins in the era of Machine Learning
COST Action CA21160
CONFERENCE
3rd ML4NGP MEETING on Machine Learning and Non-globular proteins
May 20-23, 2025
Vilnius, Lithuania
welcome message
Welcome to the ML4NGP Meeting 2025!
We are thrilled to invite you to the 4th ML4NGP Meeting, taking place bewteen May 20–23, 2025, in the beautiful city of Vilnius, Lithuania.
This conference brings together researchers and innovators in the field of Non-Globular Proteins (NGPs) and Machine Learning tools. It’s a unique platform to explore advancements in:
- Development of cutting-edge bioinformatic tools and databases
- Studies on repeats, intrinsically disordered regions, low-complexity regions
- Research on proteins prone to aggregation or phase separation
Whether you’re an experienced researcher or starting your journey, the ML4NGP Meeting offers a fantastic opportunity to present your work, network with peers, and exchange ideas with scientists from across Europe.
This event is hosted by the Amyloid Research Sector of the Life Science Centre, Vilnius University.
We look forward to welcoming you to Vilnius for an unforgettable experience!
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Deadline |
Status |
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Abstract submission deadline (posters & talks) |
March 14, 2025 |
Closed |
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Abstract decision |
March 24, 2025 |
Closed |
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Late abstract submission deadline (posters only) |
March 17, 2025 |
Closed |
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Registration |
April 25, 2025 |
Open |
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Conference dates |
May 20-23, 2025 |
No registration fee for this conference, only a meal package fee. See ‘Meal Fee’ information.
Follow this link to register
– 180 EUR, if you choose not to attend the social dinner.
– 200 EUR, covering all lunches, the welcome cocktail reception, and the social dinner.
Payment is to be made by wire transfer:
- Beneficiary name: VŠĮ “Amiloidas”
- IBAN: LT79 7044 0600 0820 3615
- Bank: SEB Bank AB, Vilnius, Lithuania
- SWIFT- BIC code: CBVILT2X
Participants involved in the ML4NGP COST Action who have been selected to deliver talks will be eligible for travel fellowships in accordance with COST reimbursement rules. For this event, a daily allowance of 175 Euros has been set to cover local transportation, accommodation, and food expenses. Additionally, long travel expenses (e.g., plane tickets) will be reimbursed.
Participants from ML4NGP COST Action with selected abstracts for posters will also benefit from the travel fellowship on a best effort basis
information
Presentation time
Keynote lectures | Speaking time is 35 minutes plus 5 minutes discussion.
Invited talks | Speaking time is 25 minutes plus 5 minutes discussion
Selected talks | Speaking time is 12 minutes plus 3 minutes discussion.
Flash posters | Speaking time is 5 minutes.
Poster presenters are requested to set up their posters in the designated area before each poster session starts. Presenters are expected to be available near their posters during the assigned session. Posters’ board size: A0 (841 x 1189 mm).
Speakers are required to have their presentation ready on a USB key.
Your slides should be either in .pdf, .ppt or .pptx format.
Venue
VENUE
The ML4NGP Meeting 2025 will take place at the Artis Hotel, in Vilnius, Lithuania.
CONFERENCE PROGRAM
Confirmed Keynote Speakers
Prof. John Moult
University of Maryland (USA)
Prof. Silvio Tosatto
University of Padova (IT)
Prof. Paul Robustelli
Dartmouth College (USA)
Prof. Ora Schueler-Furman
Hebrew University of Jerusalem (IL)
Prof. Alan M. Moses
University of Toronto (Canada)
Confirmed Invited Speakers
Lukas Stelzl, Johannes Gutenberg University Mainz, Germany
Joana Pereira, VIB and KU Leuven, Belgium
Sigrid Miles, Leibniz-FMP, Germany
Massimiliano Bonomi, Institut Pasteur, CNRS, France
Thorben Cordes, Technische Universität Dortmund, Germany
Michele Vendruscolo, University of Cambridge, UK
Pau Bernadó, CBS-CNRS, France
Meytal Landau, Deutsches Elektronen-Synchrotron DESY, Germany
Peter Tompa, VIB-VUB Center for Structural Biology, Belgium
Tiago Cordeiro, ITQB-NOVA University of Lisbon, Portugal
Andrei Lupas, Max-Planck-Institute for Biology, Tübingen, Germany
Arun Prasad Pandurangan, University of Cambridge, UK
Preliminary Program
Tuesday, May 20
08:00-09:00
Registration
09:00-09:15
Welcome Note
09:15-09:55
Keynote Talk
Title TBA | John Moult
09:55-10:25
Invited Talk
Conformational Dynamics of Intrinsically Disordered Proteins on the Surface of Gold Nanoclusters | Pau Bernadó
10:25-10:40
Selected Talk
On the diversity of disordered linkers in a family of multi-modular enzymes | Juan Cortes
10:40-11:10
Coffee Break
11:15-11:45
Invited Talk
Title TBA | Joana Pereira
11:45-12:00
Selected Talk
A paradigmatic example of multidomain protein studied by NMR spectroscopy: The nucleoprotein of SARS-CoV-2 | Marco Schiavina
12:00-12:15
Selected Talk
Maximum Entropy Method-Derived Conformational Ensembles: A FRET Perspective on a Floppy Foldase | Thomas-Otavio Peulen
12:15-12:30
Selected Talk
Molecular design features underlying nucleocytoplasmic transport | Barak Raveh
12:30-14:00
Lunch
14:00-15:00
WG meeting
15:00-16:30
Coffee Break and Discussion
16:30-16:45
Selected Talk
Integrative analysis of NMR and SAXS data aided with MD simulations to reveal dynamic structural features in the single alpha-helix of Drebrin | Soma Varga
16:45-17:00
Selected Talk
Proteome-wide Prediction of the Functional Impact of Missense Variants | Elodie Laine
17:00-17:15
Selected Talk
PETIMOT: A Novel Framework for Inferring Protein Motions from Sparse Data Using SE(3)-Equivariant Graph Neural Networks | Sergei Grudinin
18:00-21:00
Welcome Reception
Wednesday, May 21
08:00-09:00
Registration
09:00-09:40
Keynote Talk
Characterizing the Conformational Ensembles and Molecular Recognition Mechanisms of Intrinsically Disordered Proteins with Machine Learning | Paul Robustelli
09:40-10:10
Invited Talk
Atomic resolution ensembles of Intrinsically Disordered Proteins with Alphafold-2 | Massimiliano Bonomi
10:10-10:25
Selected Talk
Update on Alphafold problems for non-globular proteins | Dirk Linke
10:25-11:00
Coffee Break
11:00-11:30
Invited Talk
From accurate FRET studies on proteins to systematic assay design | Thorben Cordes
11:30-12:30
Flash Poster Presentations
12:30-14:00
Lunch
14:00-15:00
WG meeting
15:00-16:30
Coffee Break and Discussion
16:30-17:10
Keynote Talk
Unsupervised learning for non-globular proteins: everything I do gonna be zero-shot from now on | Alan M. Moses
17:10-17:40
Invited Talk
Studying intrinsically disordered proteins by NMR and single molecule FRET spectroscopy | Sigrid Miles
17:40-19:00
Poster Session I
Thursday, May 22
08:00-09:00
Registration
09:00-09:40
Keynote Talk
Confident modeling of non-confident interactions | Ora Schueler-Furman
09:40-10:10
Invited Talk
New protein fibers from the dark proteome | Andrei Lupas
10:10-10:25
Selected Talk
Repertoire of Side-chain Propelled Rings (SPuRs) in the C-terminal part of tau protein involved in aggregation | Rostislav Skrabana
10:25-11:00
Coffee Break
11:00-11:30
Invited Talk
Title TBA | Michele Vendruscolo
11:30-11:45
Selected Talk
Uncovering the effects of distinct membrane physical properties in tau binding to lipid vesicles and aggregation at the single-molecule level | Ana M. Melo
11:45-12:00
Selected Talk
Can AI and ML tackle the Configurational Integral of Tau Proteins? Or actually all proteins? | Radovan Dvorsky
12:00-12:15
Selected Talk
Structural Insights into Alpha-Synuclein Amyloid Fibril Polymorphism via Cryo-EM | Darius Sulskis
12:15-12:30
Selected Talk
Investigating the architecture and dynamics of Cdc48-cofactor interactions through structural mass spectrometry and integrative modeling | Tal Oppenheim
12:30-14:00
Lunch
14:00-14:30
Invited Talk
Virulent and antimicrobial amyloids | Meytal Landau
14:30-15:00
Invited Talk
Title TBA | Peter Tompa
15:00-16:00
Round-Table
Machine Learning Meets Disorder: Bridging Academia and Industry in Non-Globular Protein Research
16:00-16:30
Coffee Break
16:30-18:00
Poster Session II
19:00-22:00
Social Dinner
Friday, May 23
09:00-09:40
Keynote Talk
CAID-3 and beyond | Silvio Tosatto
09:40-10:10
Invited Talk
Title TBA | Arun Prasad Pandurangan
10:10-10:25
Selected Talk
Generating temperature-dependent structural ensembles of proteins with machine learning | Giacomo Janson
10:25-11:00
Coffee Break
11:00-11:30
Invited Talk
Title TBA | Lukas Stelzl
11:30-12:15
Selected Talk
Sequence Features of IDRs Shape Linker Ensembles in the Context of Folded Domains | Hamidreza Ghafouri
11:30-12:15
Selected Talk
GeomeTRe: A Python package for accurate estimation of geometrical parameters of Structured Tandem Repeat Proteins (STRPs) | Zarifa Osmanli
11:30-12:15
Selected Talk
LCRPlatform: A Comprehensive Metaserver for Functional and Evolutionary Exploration of Low-Complexity Regions | Aleksandra Gruca
12:15-13:45
Lunch
13:45-14:15
Invited Talk
Dynamic ensembles of SARS-CoV-2 N-protein reveal head-to-head coiled-coil-driven oligomerization and phase separation | Tiago Cordeiro
14:15-14:45
Selected Talk
Scanning coiled-coil fibers piecewise reveals local folding propensities | Mikel Martinez Goikoetxea
14:15-14:45
Selected Talk
Energetic Frustration as a Determinant of Intrinsic Disorder in Proteins | Edgar Pedro Chacón Sánchez
14:45-15:00
Closing Remarks
ORGANIZATION
LOCAL ORGANIZING COMMITTEE
Darius Šulskis, Vytautas Smirnovas, Mantas Žiaunys, Andrius Sakalauskas, Kamilė Mikalauskaitė and Rūta Sniečkutė from the Institute of Biotechnology, Life Sciences Center, Vilnius University, Lithuania
SCIENTIFIC COMMITTEE
Core Group of ML4NGP COST Action
contact information
Information and inquiry: info@ml4ngp.eu
SPONSORS
This event is part of the activities of the COST Action ML4NGP, CA21160, supported by COST (European Cooperation in Science and Technology).